T Cell Anergy & Tolerance
Suboptimal antigen stimulation induces transcriptional and
metabolic programs that enforce T-cell unresponsiveness.
We identify the molecular mechanisms that establish
and maintain antigen-specific tolerance.
CAR-T Therapy for Solid Tumors
Solid tumors create an immunosuppressive
microenvironment that limits CAR-T cell activity.
We engineer CAR-T cells to improve trafficking,
persistence, and anti-tumor function.
Breaking Tumor Tolerance
Tumors induce antigen-specific tolerance
that limits T-cell activity.
We engineer genetically modified T cells to overcome
tolerance and enhance anti-tumor immunity.