논문 - Laboratory of Molecular Immunology

CKH’s Lab publication

Bold: our lab members, ^*first authors, ⁺corresponding authors

Featured publications

35. Lee Y^*, Kim S, Lee S, Lee JE, Jeon Y, Sim K, Park HB, Park S, Choi EY, Chae J, Darcy P, Lee H, An J-Y and Choi K⁺, “Autophagic degradation of Akt by Ndrg1 maintains T cell exhaustion via anergy-like signaling” (Submitted) (2026).

32. Lee S^*, Lee J^*, Park HB, Kim JW, Jeong DS, Lim HJ, Lee YJ, Kim JH, Choi EY, Son WC, Cho SY and Choi K⁺, “Auto- and trans-ligation of CTLA4-CD28 chimera potentiates CAR-T cells using T and B cells” (In revision) (2026).

30. Nam G^*, Yeon HR, Park HB, Chang H, Kim JH, Cho B-K, Jung H, Yi EC, Kim S, An J-Y, Lee JE, Lee Y, Lee S, Lim H, Shon W-J, Hwang EM, Ryu H, Chang J, Choi K⁺ and Choi EY⁺, “CD99-mediated immunological synapse formation potentiates CAR-T cell function” Nature Communications 16, 7987 (2025).

29. Park HB^*, Kim KH, Kim JH, Kim SI, Oh YM, Kang M, Lee S, Hwang S, Lee H, Lee TJ, Park S, Lee JE, Jeong GR, Lee DH, Youn H, Choi EY, Son WC, Chung SJ⁺, Chung J⁺ and Choi K⁺, “Improved safety of chimeric antigen receptor T cells indirectly targeting antigens via switchable adapters” Nature Communications 15, 9917 (2024).

28. Kim JH^*, Kim H, Lee A-N, Park HB and Choi K⁺, “Monovalent Anti-CD3 Antibodies Effectively Eliminate the TCR-Positive Fraction of TCR-Deleted Allogeneic CAR-T Cells to Prevent GVHD” Immune Network 24(6), e43 (2024).

18. Ju J-M, Jung MH, Nam G, Kim W, Oh S, Kim HD, Kim JY, Chang J, Lee SH, Park GS, Min C-K, Lee D-S, Kim MG, Choi K and Choi EY⁺, “Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen” Nature Communications 9, 225 (2018).

17. Park HB^*, Lee JE, Oh YM, Lee SJ, Eom H-S⁺ and Choi K⁺, “CTLA4-CD28 chimera gene modification of T cells enhances the therapeutic efficacy of donor lymphocyte infusion for hematological malignancy” Experimental & Molecular Medicine 49, e360 (2017).

14. Kim J, Ryu SJ, Oh K, Ju J-M, Jeon JY, Nam G, Lee D-S, Kim H-R, Kim JY, Chang J, Sproule T, Choi K, Roopenian D and Choi EY⁺, “Memory programming in CD8+ T-cell differentiation is intrinsic and is not determined by CD4 help” Nature Communications 6, 7994 (2015).

13. Oh YM^*, Park HB^*, Shin JH, Lee JE, Park HY, Kho DH, Lee JS, Choi H, Okuda T, Kokame K, Miyata T, Kim I-H, Lee SH, Schwartz RH and Choi K⁺, “Ndrg1 is a T-cell clonal anergy factor negatively regulated by CD28 costimulation and interleukin-2” Nature Communications 6, 8698 (2015).

9. Shin JH^*, Park HB, Oh YM, Lim DP, Lee JE, Seo HH, Lee SJ, Eom HS, Kim I-H, Lee SH and Choi K⁺, “Positive conversion of negative signaling of CTLA4 potentiates antitumor efficacy of adoptive T-cell therapy in murine tumor models” Blood 119(24), 5678-5687 (2012).

All publications

2026

34. Shin S, Hong S-P, Lee S, Jang Y, Yang J, Oh J, Jang D, Lee S-J, Kim J, Lee SE, Yang Y, Kim D, Yang E, Park S, Hwang S, Choi AJ, Jung HR, Oh Y, Lee C-H, Cho J-Y, Choi K, Bae JM⁺, Kim J-I⁺ and Cho S-Y⁺, “KRAS mutations reprogram RNA m6A modifications to drive CD73-dependent immune evasion in colorectal cancer” Cancer Research (2026).

33. Jung H, Jeong B, Kim Y-W, Jung C, Lee S, Uhm H, Kim H, Oh YE, Park Y, Lee Y, Kang M, Im HW, Kim D, Lee S, Kim Y, Choi K and Bae S⁺, “Precise genomic integration of large DNA fragments by donor-directed annealing using prime editing” Nature Biotechnology (In press).

31. Hur YJ, Song YK, Lee JY, Song HS, Lee SH, Ko MJ, Kwon HJ, Rhee HW, Choi K, Park SK, Kim SW, Lee MS and Lee YT⁺, “T cell receptor signaling remodels mitochondria-ER contact sites to regulate T cell function and antitumor immunity” (Submitted).

2025

2024

Earlier studies

27. Lee, S., Lee, H. T., Kim, Y. A., Lee, I. H., Kang, S. J., Sim, K., Park, C. G., Choi, K. H., & Youn, H. D. The optimized core peptide derived from CABIN1 efficiently inhibits calcineurin-mediated T-cell activation. Experimental and Molecular Medicine54(5), 613-625. (2022)

26. Shin, S. P., Goh, A. R., Ju, J. M., Kang, H. G., Kim, S. J., Kim, J. K., Park, E. J., Bae, Y. S., Choi, K. H., Jung, Y. S. & Lee, S. J. Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-β-catenin-driven M2 macrophage. Molecular Therapy – Oncolytics23, 138-150. (2021)

25. Ju, J. M., Nam, G., Lee, Y. K., Jung, M., Chang, H., Kim, W., Shon, W. J., Lim, J. Y., Kim, J. Y., Chang, J., Min, C. K., Lee, D. S., Choi, K. H., Shin, D. M. & Choi, E. Y. IDO1 scavenges reactive oxygen species in myeloid-derived suppressor cells to prevent graft-versus-host disease. PNAS118(10), e2011170118. (2021)

24. Kim, D. H., Kim, H. Y., Cho, S., Yoo, S. J., Kim, W. J., Yeon, H. R., Choi, K. H., Choi, J. M., Kang, S. W. & Lee, W. W. Induction of the IL-1RII decoy receptor by NFAT/FoxP3 blocks IL-1β-dependent response of TH17 cells. eLife10, e61841. (2021)

23. Sim, J. H., Kim, J. H., Park, A. K., Lee, J., Kim, K. M., Shin, H. M., Kim, M., Choi, K.H., Choi, E. Y., Kang, I., Lee, D. S. & Kim, H. R. IL-7Rα low CD8+ t cells from healthy individuals are anergic with defective glycolysis. Journal of Immunology205(11), 2968-2978. (2020)

22. Choi, E. Y., Choi, K. H., Nam, G., Kim, W. & Chung, M. H60: A Unique Murine Hematopoietic Cell-Restricted Minor Histocompatibility Antigen for Graft-versus-Leukemia Effect. Frontiers in Immunology11, 1163. (2020)

21. Yoo, I. H., Kim, W., Choi, S. A., Kim, S. Y., Kim, H., Lim, B. C., Hwang, H., Choi, J., Kim, K. J., Kim, Y., Hyun, J. W., Kim, S. H., Choi, K. H., Kim, H. J. & Chae, J. H. Clinical spectrum of myelin oligodendrocyte glycoprotein-immunoglobulin g-associated disease in Korean children. Journal of Clinical Neurology16(3), 461-469. (2020)

20. Kim, Y., Hyun, J. W., Woodhall, M. R., Oh, Y. M., Lee, J. E., Jung, J. Y., Kim, S. Y., Lee, M. Y., Kim, S. H., Kim, W., Irani, S. R., Waters, P., Choi, K.H.*& Kim, H. J. Refining cell-based assay to detect MOG-IgG in patients with central nervous system inflammatory diseases. Multiple Sclerosis and Related Disorders40, 101939. (2020)

19. Lee, S. H., Soh, H., Chung, J. H., Cho, E. H., Lee, S. J., Ju, J. M., Sheen, J. H., Kim, H., Oh, S. J., Lee, S. J., Chung, J., Choi, K. H., Kim, S. Y. & Ryu, J. S. Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging. PLoS ONE15(1), e0223814. (2020)

18. Ju, J. M., Jung, M. H., Nam, G., Kim, W., Oh, S., Kim, H. D., Kim, J. Y., Chang, J., Lee, S. H., Park, G. S., Min, C. K., Lee, D. S., Kim, M. G., Choi, K. H.*& Choi, E. Y. Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen. Nature Communications9(1), 225. (2018)

17. Park, H. B., Lee, J. E., Oh, Y., Lee, S. J., Eom, H. S. & Choi, K. H.*CTLA4-CD28 chimera gene modification of t cells enhances the therapeutic efficacy of donor lymphocyte infusion for hematological malignancy. Experimental and Molecular Medicine49(7), e360. (2017)

16. Kim, Y., Kim, G., Kong, B. S., Lee, J. E., Oh, Y. M., Hyun, J. W., Kim, S. H., Joung, A. R., Kim, B. J., Choi, K. H.*& Kim, H. J. Large-scale in-house cell-based assay for evaluating the serostatus in patients with neuromyelitis optica spectrum disorder. Journal of Clinical Neurology13(2), 175-180. (2017)

15. Shin, J. H., Park, H. B. & Choi, K. H.*Enhanced anti-tumor reactivity of cytotoxic T lymphocytes expressing PD-1 decoy. Immune Network16(2), 134-139. (2016)

14. Kim, J., Ryu, S. J., Oh, K., Ju, J. M., Jeon, J. Y., Nam, G., Lee, D. S., Kim, H. R., Kim, J. Y., Chang, J., Sproule, T., Choi, K. H.*, Roopenian, D. & Choi, E. Y. Memory programming in CD8+ T-cell differentiation is intrinsic. Nature Communications6, 7994. (2015)

13. Oh, Y. M., Park, H. B., Shin, J. H., Lee, J. E., Park, H. Y., Kho, D. H., Lee, J. S., Choi, H., Okuda, T., Kokame, K., Miyata, T., Kim, I. H., Lee, S. H., Schwartz, R. H. & Choi, K. H.*Ndrg1 is a T-cell clonal anergy factor. Nature Communications6, 8698. (2015)

12. Goh, A. R., Shin, S. P., Jung, N. R., Ryu, C. H., Eom, H. S., Lee, J. H., Choi, K. H.*, Lee, S. J. & Jung, Y. S. Low-dose cisplatin converts the tumor microenvironment. Cancer Letters356(2), 743-750. (2015)

11. Kim, J. H., Yoon, E. K., Chung, H. J., Park, S. Y., Hong, K. M., Lee, C. H., Lee, Y. S., Choi, K. H.*, Yang, Y., Kim, K. & Kim, I. H. P53 acetylation enhances Taxol-induced apoptosis. Apoptosis18(1), 110-120. (2013)

10. Shin, S. P., Seo, H. H., Shin, J. H., Park, H. B., Lim, D. P., Eom, H. S., Bae, Y. S., Kim, I. H., Choi, K. H.*& Lee, S. J. Adenovirus expressing both thymidine kinase and soluble PD1. Molecular Therapy21(3), 688-695. (2013)

9. Shin, J. H., Park, H. B., Oh, Y. M., Lim, D. P., Lee, J. E., Seo, H. H., Lee, S. J., Eom, H. S., Kim, I. H., Lee, S. H. & Choi, K. H.*Positive conversion of negative signaling of CTLA4. Blood119(24), 5678-5687. (2012)

8. Kim, W., Lee, J. E., Li, X. F., Kim, S. H., Han, B. G., Lee, B. I., Kim, J. K., Choi, K. H.*& Kim, H. J. Quantitative measurement of anti-aquaporin-4 antibodies by ELISA. Multiple Sclerosis Journal18(5), 578-586. (2012)

7. Cho, S. Y., Jeong, E. M., Lee, J. H., Kim, H. J., Lim, J., Kim, C. W., Shin, D. M., Jeon, J. H., Choi, K. H.*& Kim, I. G. Doxorubicin induces the persistent activation of intracellular transglutaminase 2. Molecules and Cells33(3), 235-241. (2012)

6. Kwak, H. J., Kim, Y. J., Chun, K. R., Woo, Y. M., Park, S. J., Jeong, J. A., Jo, S. H., Kim, T. H., Min, H. S., Chae, J. S., Choi, E. J., Kim, G., Shin, S. H., Gwak, H. S., Kim, S. K., Hong, E. K., Lee, G. K., Choi, K. H., Kim, J. H. & Yoo, H., Park, J. B. & Lee, S. H. Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas. Oncogene30(21), 2433-2442. (2011)

5. Kim, Y. H., Sung, H. J., Kim, S., Kim, E. O., Lee, J. W., Moon, J. Y., Choi, K. H., Jung, J. E., Lee, Y., Koh, S. S., Rhee, S. G., Heo, K. & Kim, I. H. An RNA aptamer that specifically binds PAUF. Cancer Letters313(1), 76-83. (2011)

4. Hong, D. M., Kim, C. S., Eom, W., Choi, K. H., Oh, Y. J., Jung, S. J. & Kim, H. S. Interactions of midazolam and propofol on GABAA receptors. Anesthesia and Analgesia112(5), 1096-1102. (2011)

3. Eom, W., Lee, J. M., Park, J., Choi, K. H., Jung, S. J. & Kim, H. S. The effects of midazolam and sevoflurane on the GABAA receptors. Korean journal of anesthesiology60(2), 109-118. (2011)

2. Cho, S. Y., Choi, K. H., Jeon, J. H., Kim, C. W., Shin, D. M., Lee, J. B., Lee, S. E., Kim, C. S., Park, J. S., Jeong, E. M., Jang, G. Y., Song, K. Y. & Kim, I. G. Differential alternative splicing of human transglutaminase 4. Experimental and Molecular Medicine42(4), 310-318. (2010)

1. Lee, J. S., Lee, J. E., Oh, Y. M., Park, J. B., Choi, H., Choi, C. Y., Kim, I. H., Lee, S. H. & Choi, K. H.*Recruitment of sprouty1 to immune synapse regulates T cell receptor signaling. Journal of Immunology183(11), 7178-7186. (2009)